Categories
Microbiology

Study reveals role of hormone in heart disease risk

Scientists at the University of Veterinary Medicine, Vienna have shed light on the role of phosphate-rich foods in raising blood pressure and promoting vascular calcifications.

Levels of a hormone known as Fibroblast Growth Factor 23 (FGF23) are increased as a result of a high-phosphate diet and this puts a strain on the cardiovascular system. 

Foods that are high in phosphates include processed cheese, Parmesan, cola, baking powder and most processed foods. Phosphates are also frequently used in the food industry as preservatives and pH stabilizers.

Chronic kidney disease affects more than 500 million people around the world. Clinical studies have shown that such people are prone to developing cardiovascular diseases such as high blood pressure and vascular calcification.

However, until recently, the link between renal disease, the build-up of the hormone FGF23, which is produced in the bones, and cardiovascular disease was unclear.  

The scientists demonstrated that FGF23 controls the reabsorption of filtered sodium in the kidneys. Mice lacking this hormone excrete higher quantities of sodium in their urine, resulting in low blood pressure. 

Those with high levels of FGF23, however, show increased levels of sodium in their blood, and in turn, high blood pressure.

Increased levels of FGF23 place a strain on the heart. "In patients with chronic renal disease, both the phosphate levels and the levels of FGF23 are chronically high. This often leads to cardiovascular disease," said Reinhold Erben, the head of the Unit of Physiology, Pathophysiology and Biophysics at the Vetmeduni Vienna.

A second study reveals that FGF23 controls calcium levels in the blood. Too much of the hormone encourages the kidneys to take up calcium, leading to vascular calcification.

FGF23 is formed in the bones and controls the excretion of phosphate via the kidneys. When abnormally high levels of phosphate are found in the body, FGF23 levels rise, leading to the excretion of excess phosphate.

If the excretion process via the kidneys does not work correctly, or too much phosphate is taken in with food, phosphate and FGF23 levels increase, resulting in a spiral which could have damaging health consequences.

Categories
HR Information

Hierarchies ‘are undermining leadership development’

Rigid organisational hierarchies are acting as a barrier to improving management and leadership skills at work.

This is according to the Chartered Institute of Personnel and Development (CIPD), which has published a new report into the topic, entitled 'Leadership – easier said than done'.

HR staff have a key role to play in addressing this situation, the organisation claims. They can do so by taking steps such as training individual leaders and improving the leadership capacity of the organisation as a whole.

Many employees who do not have formal managerial experience are now expected to "own the organisation's agenda", the CIPD claims.

As part of an approach known as 'distributed leadership', they are expected to "lead from the front" and do the right thing.

Poorly targeted training and restrictive organisational structures are serving to prevent management improvement that would help business growth and productivity, however.

Ksenia Zhelthoukhova, research adviser at the CIPD, said: "The fast-moving pace of change in the world requires a more distributed approach to leadership.

"However, our concern is that rigid organisational systems, characterised by hierarchy, short-term focus, individualism and 'us' and 'them' mentality, stifle the productivity of employees, undermining their ability to lead on the organisational agenda from the front line."

Leadership development in some organisations relies too heavily on developing the capability of individual leaders and managers, the report claims.

Outdated organisational structures and cultures can prevent potential leaders from applying what they've learnt in the training room to their work.

HR personnel can help to improve the situation by exploring the kind of leaders their organisation requires and seeing whether they would be supported by its structure.

Once priority areas have been identified, leadership training and development can be aligned to the requirements of an organisation.

HR can also play a key role by identifying people with the leadership qualities that are necessary to change the status quo. This must go beyond implementing formal processes; it should also encompass understanding where individuals are demonstrating leadership behaviours and where changes can be made in the structure of the organisation.

Categories
Microbiology

UA scientists make liver disease breakthrough

Scientists at the University of Arizona (UA) have made a breakthrough in the study of end-stage liver disease that could help to develop new treatments for the condition.

End-stage liver disease goes hand-in-hand with oxidative stress – damage to body tissues caused by reactive oxygen molecules or free radicals, which occur naturally as a result of the body's metabolic processes. 

A number of mechanisms are employed by cells to keep these free radicals under control, most of which involve a protein known as Nrf2. This activates biochemical processes that capture reactive oxygen molecules or dispose of damaged cellular components before they can cause more trouble.

When no oxidative stress response is needed, an enzyme known as Keap1 keeps levels of Nrf2 low.

According to conventional wisdom, conditions of oxidative stress lead the body to activate the  the Nrf2-mediated protection pathway in order to limit the damage caused by the destructive oxygen compounds. However, contrary to expectations, this mechanism is not activated during liver cirrhosis. 

Donna Zhang, a professor in the UA Department of Pharmacology and Toxicology, said "This was a puzzle before we did our study. Somehow the protective mechanism mediated by Nrf2 is compromised by another factor, other than Keap1, in liver cirrhosis."

Additionally, drugs aimed at inhibiting Keap1 from chewing up Nrf2 have proven ineffective in a cirrhotic liver.

A study of tissue samples revealed the reason behind the observation. Another enzyme, known as Hrd1, breaks down Nrf2 and prevents the much-needed antioxidant response, exacerbating the disease process.

Hrd1 – part of cells' waste disposal mechanism –  specialises in destroying misfolded proteins before they can accumulate and damage cell components.

Levels of Hrd1 are low under normal conditions so it does not interfere with Nrf2. But as liver cirrhosis progresses, excessive inflammation triggers the waste-mediated stress response, Hrd1 becomes very abundant and begins chewing up Nrf2.

New therapeutic treatments could be developed as a result of the scientists' insights. The team were able to restore Nrf2 levels in cirrhotic liver tissue by inactivating Hrd1 in experiments, effectively reversing liver cirrhosis in mice.

Categories
HR Information

Govt launches science investment consultation

A consultation launched by the government is asking for the views of the scientific community on how science funding should be invested.

The Department for Business, Innovation and Skills (BIS) is looking to record the opinions of a wide range of organisations from the UK scientific community, including small and medium enterprises, multinationals, universities, students and think tanks.

It says funding could be allocated for a multitude of purposes, from refurbishing a university laboratory to investing in a new major international project.

The news follows chancellor George Osborne's pledge to invest long-term in science and infrastructure, increasing capital investment to £1.1 billion and growing it in line with inflation each year to 2020.

Commenting on the consultation's launch, minister for universities and science David Willetts said: "Today's launch of our consultation on future capital investment is a historic opportunity for British science.

"The next five years will see the largest ever sustained capital spend on science investment. Our scientists can identify the next Crick Institute or the next equivalent of the Laboratory of Molecular Biology for us to invest in."

The consultation will provide evidence for the government's Science Capital Roadmap, which is to set out a long-term strategic vision for a world-leading science and research infrastructure. It will be published during the autumn.

A series of questions is available on the BIS website, inviting organisations to give their views on how the money should be spent.

The government is hoping to maintain the UK's position at the forefront of scientific innovation. Although the country has just one per cent of the world's population, 16 per cent of the highest-quality scientific articles are published in the UK.

Investing in science is necessary to support the coalition's industrial strategy and to maintain the international competitiveness of UK research.

The government says it expects greater investment to elicit a number of responses from the research community, resulting in greater collaboration, better equipment sharing and improved access for industry.

Categories
HR Information

Leaders ‘should build trust by showing their personal side’

Leaders need to reveal their personal side if they are to restore levels of trust among workforces.

This is the conclusion of the Chartered Institute of Personnel and Development (CIPD) and the University of Bath, which have produced a new report entitled 'Cultivating trustworthy leaders'. 

HR staff have a particularly significant role to play in this area, as they have a number of means at their disposal to ensure trustworthy leaders are recruited and developed. 

The research states that leaders need to share their personal stories and take an interest in the personal experiences of their employees if they wish to maintain long-lasting, trusting relationships.

People still experience high levels of uncertainty regarding their future and now require "a greater and more overt demonstration of trustworthiness from their leaders".

HR methods that could be used to help address the issue include conducting values-based interviews, providing information on self-awareness, assessing staff using 360-degree feedback, creating environments where staff could have open conversations about trust and visibly rewarding trustworthy behaviours.

However, the study also found that HR departments currently have too many rules and policies in place which could damage trust, as they suggest departments do not have confidence in employees.

Individuals have little incentive to earn trust in such environments, as there are few opportunities for them to demonstrate their reliability.

Claire McCartney, research adviser at the CIPD, said: "It's proven that organisations with high levels of trust perform better in terms of innovation, problem solving, engagement and knowledge sharing. 

"Given the recent crises in trust in the banking and healthcare sectors in particular, it's more important than ever that HR steps up to provide the appropriate platforms for trustworthy leaders to develop."

She added that HR departments need to allow leaders to flourish and should not focus too much on process and technology.

The CIPD and the University of Bath studied 13 organisations with experience of retaining and developing trustworthy leaders. Their findings build upon an earlier report entitled 'Where has all the trust gone?'

Categories
Microbiology

Gene therapy developed to reverse memory loss in mice

Researchers from the Institute of Neuroscience at the Universitat Autonoma de Barcelona (UAB) have developed a gene therapy that could pave the way for new Alzheimer's disease treatments.

One reason why attempts to devise a treatment have hitherto been unsuccessful is a lack of knowledge on the cellular mechanisms which cause alterations in nerve transmissions and the loss of memory in the initial stages of the disease.

However, the UAB researchers have discovered the cellular mechanism behind memory consolidation. Their gene therapy was able to reverse memory loss in mice models with the initial stages of the disease.

They achieved this by injecting into the hippocampus a gene which causes the production of a protein blocked in patients with Alzheimer's, the "Crtc1" (CREB regulated transcription coactivator-1).

The protein thus restored gives way to the signals needed to activate the genes involved in long-term memory consolidation.

In order to identify the gene, gene expression in the hippocampus of healthy control mice was compared with that of transgenic mice which had developed the disease.

The team used DNA microchips to identify the genes and proteins which expressed themselves at different stages of the disease. 

It was found that those genes involved in memory consolidation coincided with the genes regulating Crtc1, a protein which also controls genes related to the metabolism of glucose and to cancer. Altering this group of genes could cause memory loss in the initial stages of Alzheimer's.

The formation of amyloid plaque aggregates, which cause Alzheimer's, prevents the proper functioning of the Crtc1 protein.

"When the Crtc1 protein is altered, the genes responsible for the synapsis or connections between neurons in the hippocampus cannot be activated and the individual cannot perform memory tasks correctly," explained Carlos Saura, researcher of the UAB Institute of Neuroscience and head of the research. 

Mr Saura said new perspectives on therapeutic prevention have been opened up by the research, as they have demonstrated the effectiveness of gene therapy in preventing the loss of memory in mice.

Alzheimer's disease affects almost 500,000 people in the UK, making it the most common form of dementia.

Categories
HR Information

HR ‘can do more to create effective dialogue’

A leading communications expert says HR departments have an important role to play in developing a clear communications strategy that will engage staff.

According to Karen Heath, chief engagement officer of Anthony Hodges Consulting, communications should be tailored to the needs of employees whenever possible.

Many companies do not take this approach, HR Magazine reports, often opting for a blanket communication sent to all staff rather than addressing each employee individually. Time and resource constraints tend to prevent organisations from taking the latter approach.

Ms Heath said it is worth questioning the efficacy of communications that fail to resonate with up to half of a firm's workforce.

Staff in separate locations often feel disengaged as a result of a "head office centric" approach to communications, she added.

Employers need to bear in mind local practices, economies and events, which can often have an impact on employees' financial situations.

"With ever more diverse workforces in the future, the idea of getting the message across effectively to every employee will become even more important," she said. 

"If you look at auto-enrolment in pensions, the message that you give employees in their twenties should be very different to those approaching retirement."

Changing shift patterns can also present challenges for communications, Ms Heath said. Audience analysis and research is vital before embarking on any communications campaign.

Ms Heath's comments highlight the importance of effective communication to ensure staff engagement levels are maintained.

In March, Martin Reed, the chief executive officer and chairman of psychometric people management tool provider Thomas International, said better communication is needed to ensure firms retain top talent.

He said both staff and management are often reluctant to have difficult conversations in the workplace and that frequent one-to-one discussions and conversations about problems that may arise are essential to maintaining engagement levels.

According to Mr Reed, such an approach is necessary because employees are likely to look for opportunities elsewhere as the economy continues to recover and this could pose problems for some organisations.

Categories
Microbiology

Scientists discover role of protein in combating cancer

Researchers have identified a new 'dustbin' role for a molecule that helps a drug to kill cancer cells.

The new study, published in the journal Proceedings of the National Academy of Sciences on Monday April 21st, could be used to develop a test to identify patients who would be most responsive to a new class of cancer drugs and those who may develop resistance, as well as suggesting new approaches to discovering more effective drugs.

Researchers found that a molecule, known as Cullin-5 (CUL5), acts as a combined cleaner and dustman, sweeping up proteins that tell cancers to divide continuously and consigning them to a cellular 'dustbin'.

CUL5 works in opposition to another important molecule known as HSP90, which scientists have been trying to block with drugs to prevent cancer cells from dividing.

When the scientists treated cancer cells with drugs that block HSP90, they found that the cleaning protein CUL5 stepped in to dispose of the proteins that were telling the cells to keep dividing.

They also discovered an additional function of CUL5, showing that it helps to pull the 'dividing-signal' proteins away from the protective shelter of HSP90, effectively stopping cancer in its tracks by labelling the cells with a tag that sends them to the cellular dustbin.

Professor Paul Workman, study lead and deputy chief executive of The Institute of Cancer Research, said drugs that block HSP90 have previously been identified as a potential treatment for cancers and the team knew CUL5 may play a role in these drugs' function.

"Our new research shows that CUL5 is not only vital in the response of cancer cells to HSP90 inhibitors but also reveals surprising insights into precisely how it works by acting at several different levels," he added.

Professor Workman said he was surprised by the high number of cancer-causing proteins CUL5 helps to dispose of and the fact that it works across several types of tumour.

The researchers said patients may be resistant to HSP90-blocking drugs if their cells have low levels of CUL5, while the drugs may work better in those with high levels of the molecule. 

Categories
Microbiology

DNA looping damage ‘could play role in HPV-related cancers’

Researchers at the Ohio State University have shed light on the way in which certain strains of human papillomavirus (HPV) cause cancer.

They found that the virus disrupts the human DNA sequence with repeating loops when it is inserted into host-cell DNA as it replicates.

Around 610,000 cases of cancer per year are caused by HPV. This accounts for about five per cent of all cases of the disease and virtually all incidences of cervical cancer. The mechanisms behind the process are not yet completely understood, however.

The team of scientists utilised the immense computational power of the Ohio Supercomputer Center to carry out their research. 

A variety of techniques, including whole-genome sequencing and genomic alignment, were used to examine ten cancer-cell lines and two head and neck tumour samples from patients.

David Symer, assistant professor of molecular virology, immunology and medical genetics at Ohio State's Comprehensive Cancer Center, said: "HPV can act like a tornado hitting the genome, disrupting and rearranging nearby host-cell genes. 

"This can lead to overexpression of cancer-causing genes in some cases, or it can disrupt protective tumour-suppressor genes in others. Both kinds of damage likely promote the development of cancer."

Co-senior author Professor Maura Gillison explained that they observed fragments of host cell genome being removed, rearranged or increased in number at sites of HPV insertion.

These were accompanied by increases in the number of HPV copies in the host cell, while the expression of cancer-promoting genes viral E6 and E7 was also increased.

Although E6 and E7 are essential for the development of cancer, they are not alone sufficient to cause it. Researchers believe the destabilising loops may play a key role, providing additional alterations that promote cancer development, as genomic instability is a hallmark of cancers.

Professor Symer said the team's research shows what happens during the 'end game' of cancer development. He added that it sheds light on the steps between initial infection with a HPV to the development of a related cancer.

Categories
HR Information

Poll finds HR professionals welcome early conciliation

Two-thirds of HR professionals welcome the introduction of early dispute settlement by the Advisory, Conciliation and Arbitration Service (Acas).

This is according to a poll conducted by Personnel Today, which reveals that 65.3 per cent of respondents believe early conciliation constitutes a positive step in tackling workplace disputes. 

Just 6.3 per cent of those polled disagreed with the statement, while 28.4 per cent were undecided.

Gill McCarthy, director of operational policy and performance at Acas, said it was positive from the perspective of her organisation that most respondents welcomed early conciliation.

Most of the audience of a live webinar held by Personnel Today (52.5 per cent) believe the level of tribunal fees is about right, while 28.4 per cent think they are too low and 12.7 per cent oppose them entirely. Just 6.3 per cent said they thought fees are too low.

Acas recently announced the introduction of the early conciliation service, which means claimants will need to contact the organisation before lodging an employment tribunal claim from May 6th.

The process is designed to save people the time, cost and anxiety involved in undergoing an employment tribunal.

Independent research has found that the pre-claim conciliation (PCC) process – the forerunner of early conciliation – has benefited the British economy by around £19 million.

Over three quarters of the 20,000 cases a year that the PCC has dealt with were not referred to an employment tribunal. 

The research also found that the average cost to employers of claims dealt with through PCC was just £475, with employers spending an average of just one day on a claim. This compares with an average of £3,700 and four days for an employment tribunal.

Acas chair Sir Brendan Barber said: "Early conciliation will give us the chance to help even more people resolve their disputes early as well as save taxpayers some of the cost of running the tribunal system."

The polls were conducted during a live webinar held on April 9th, with the vast majority of respondents describing themselves as HR professionals. The number of respondents ranged between 891 and 901.