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Micro-biology

Stem cell research helps shed light on spread of cancer

New research conducted into breast cancer cells has identified two states in which they exist and each of these plays a role in the spread of the disease.

"The lethal part of cancer is its metastasis so understanding how metastasis occurs is critical," says senior study author Max Wicha, MD, distinguished professor of oncology and director of the University of Michigan Comprehensive Cancer Center. "We have evidence that cancer stem cells are responsible for metastasis – they are the seeds that mediate cancer’s spread. Now we’ve discovered how the stem cells do this."

A type of stem cell exists on the outside of the tumour known as the epithelial-mesenchymal transition (EMT) state. These cells are able to enter the bloodstream and travel to distant parts of the body.

The cells transform into a second state, the mesenchymal-epithelial transition state (MET), when they reach their destination. These cells are able to produce new tumours by growing and copying themselves.

Both forms of cancer stem cells are necessary if cells are to metastasise and grow in other organs. They are unable to do this if only one or the other is present.

The team's findings have implications for breast cancer treatments, as researchers must now find out whether potential cures need to target both types of stem cell. As each type of stem cell is regulated by a different pathway, it may be that effective therapies have to target multiple pathways.

It may also pave the way for new testing methods. Currently, EMT cells do not seem to be captured by the tests for tumour cells circulating in the blood – and these are the cancer cells that travel through the bloodstream.

University of Michigan researchers are currently collaborating with a team from the university's College of Engineering to develop ways of isolating the EMT cells. Identifying the stem cells will enable the team to use markers to improve the effectiveness of treatments.

Although the study focussed on breast cancer, the findings may also apply to other types of the disease.

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HR Information

Organisations ‘should do more to retain talent’

A report on the UK jobs market in 2014 predicts increased talent migration and suggests businesses are not doing enough to retain their best employees.

A combination of improving prospects for job candidates and a lack of talent management strategies among organisations will pose problems for firms looking to retain their best employees.

Reed Salary and Market 2014 report reveals 61 per cent of HR professionals are worried about losing talent during the coming year. Despite this, 62 per cent admit to having no talent management strategy in place 

In addition, over 44 per cent of HR professionals are expected to look for a new job. 

More than half (54 per cent) of HR employees said they had not received a pay rise in the past 12 months.

The market for prospective candidates is improving, the report suggests, as job opportunities are up 28 per cent year-on-year.

Tom Lovell, group managing director at REED, said the majority of HR employees are satisfied in their current jobs but businesses could not afford to overlook the fact that competition for the best-quality candidates would increase as the economy improves.

"Despite a need to attract and retain talent within their organisation, many businesses aren’t investing in their workforce through pay or their benefits, such as training, and this will impact on the overall satisfaction rating for their workforce," he commented. 

He said organisations would need to invest in brand reputation and talent management to ensure they recruit and retain the best individuals.

The Reed publication follows a report from Deloitte stating that talent would be the focus of HR in 2014, as employers would have to do more to retain and engage their workforces.

Skills would be in short supply, Deloitte predicted, and organisations would have to create global networks in order to win the race for talent.

Talent mobility would force organisations to open up access to internal positions, employee assessment tools and encourage leadership values that focus on internal development.

Categories
Micro-biology

New gene research raises hopes for brain tumour treatment

Scientists have identified a mutated gene which causes a particularly debilitating kind of brain tumour, possibly leading the way to new treatments for the condition.

The only treatments currently available for the tumours, which affect less than one in 100,000 people, are repeated surgery and radiation therapy. 

Research conducted by scientists from Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Massachusetts General Hospital, and the Broad Institute of MIT and Harvard, reveals that drugs currently used to treat other kinds of tumours could be used to treat tumours known as craniopharyngiomas.

There are two types of craniopharyngiomas: adamantinomatous and papillary. They form in the base of the brain near the pituitary gland, hypothalamus, and optic nerves. 

A mutated gene known as BRAF was discovered in all samples of papillary craniopharyngiomas, which mainly occur in adults. 

The other type, adamantinomatous, occurs mainly in children. A different mutant gene was found to drive these tumours. The researchers said drugs to treat these tumours could become clinically available in the future.

"From a clinical perspective, identifying the BRAF mutation in the papillary tumors is really wonderful, because we have drugs that get into the brain and inhibit this pathway," said Sandro Santagata, MD, PhD, a co-senior author of the paper. "Previously, there were no medical treatments – only surgery and radiation – and now we may be able to go from this discovery right to a well-established drug therapy."

Malignant melanoma is currently treated using BRAF inhibitors and plans are now underway to test the effectiveness of this treatment in patients with papillary craniopharyngiomas.

Craniopharyngiomas can cause a number of debilitating conditions, including headaches, visual impairment, hormonal imbalances, obesity and short stature. Tumours often recur and, although they do not metastasise, are difficult to treat even using advanced neurosurgical techniques.

A single mutated BRAF gene was found to be the sole driver of 95 per cent of the papillary craniopharyngiomas analysed by the team with whole-exome DNA sequencing.

If the inhibitors prove successful in halting or reversing the growth of tumours, they could be used to reduce their size in order to prevent the need for major surgery.

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HR Information

Integrity and talent management are CEO priorities for 2014

New research from The Conference Board and UK partner Chartered Management Institute (CMI) suggests chief executive officers (CEOs) are adopting a focus on workers in 2014 in order to maximise growth.

Employee engagement and better management are at the heart of a drive to reshape workplace culture in order to improve competitiveness and raise productivity.

The survey, CEO Challenge, was carried out to gauge opinion among CEOs, presidents and chairmen from 1,000 companies around the world. It found that Human Capital, which encompasses developing, retaining and engaging talented employees, is currently the biggest challenge facing CEOs.

An unexpected finding from the survey is that business leaders plan to focus on their existing workforce rather than launching recruitment drives. Nine out of the top ten Human Capital strategies are focussed on existing employees, striving to maintain engagement and retain critical talent – a disappointing result for those hoping to change jobs.

Management performance is also highly important, with "improving leadership development programmes" now up to fifth on the agenda – last year, it was tenth.

Ethical working is also a high priority. Integrity was ranked highest on the list of leadership attributes that are critical to future success, suggesting bosses are looking to improve the ethical dimension of work that was so severely compromised by high-profile scandals of recent years. 

Leading change, managing complexity, an entrepreneurial mindset and the ability to retain and develop talent were the other qualities valued most highly by those surveyed.

CMI’s director of strategy Petra Wilton said CEOs are faced with the challenge of building world-class workforces. "It’s good to see European leaders in particular recognising that leadership development is critical to getting this right. Leadership attributes like integrity, leading change and managing complexity are fundamental to cracking the challenges facing managers and leaders in the year ahead, and will be absolutely key to future success."

Ms Wilton went on to say the findings support the 'Valuing Your Talent' initiative, which is being developed by CMI in partnership with the UK Commission for Employment and Skills, Chartered Institute of Personnel Development, Chartered Institute of Management Accountants, Investors in People and the Royal Society for the Arts.

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Life Sciences

New material could help treat heart defects

Researchers have developed a new adhesive that could be used to treat patients suffering from congenital heart defects.

Conventional treatments for such conditions are highly invasive and problems are posed by the need to secure the devices quickly and safely. Sutures take a long time to stitch and can put pressure on the developing heart muscle, while current adhesives are either too toxic or prone to lose their grip in the fast-flowing blood surrounding the heart.

Scientists at Boston Children's Hospital, BWH and Massachusetts Institute of Technology (MIT) have developed a bio-adhesive that could be used to rapidly attach biodegradable patches in patients suffering from heart defects. 

They were inspired by examples from nature, recognising that many creatures have secretions that are viscous and water repellent, enabling them to attach in wet and dynamic environments. They developed a material that is biodegradable, elastic and biocompatible, in addition to having viscous and water repellant properties.

The researchers found that the patches remained attached even at increased heart rates and blood pressure. 

"This adhesive platform addresses all of the drawbacks of previous systems in that it works in the presence of blood and moving structures," said Pedro del Nido, MD, chief of cardiac surgery, Boston Children's Hospital, co-senior study author. "It should provide the physician with a completely new, much simpler technology and a new paradigm for tissue reconstruction to improve the quality of life of patients following surgical procedures."

Ultraviolet light is used to activate the patch's adhesive properties, meaning an on-demand, anti-bleeding seal is put in place within five seconds of the light's application.

It is expected the seal will reduce the invasiveness of surgery as well as operating times, leading to improved surgical outcomes.

Robert Langer, ScD, MIT, and author of the study said he was delighted the materials his team developed would be used to greatly improve human lives.

A start-up company, Gecko Biomedical, based in Paris, has obtained rights to the adhesive technology and hopes to bring the adhesive to market in two to three years.

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HR Information

HR ‘should adapt to social media use’

HR will need to keep up with the effect of social media developments, which stand to have a profound effect on the structure of organisations.

A report by Accenture, Trends Reshaping the Future of HR, says social media will give workers a greater degree of independence, allowing them to define their own learning, career paths and their own performance feedback. It will be easier for workers to share knowledge and ideas, HR Magazine reports.

A new generation bringing different values and behaviours into the workplace has the potential to disrupt organisations' structures, hierarchies and titles.

Linked In HR director Connie Gibney agrees that the workplace will be increasingly shaped by these emerging trends and says HR must adapt to them.

"You only need to look at the amount of young people coming into the workplace who use LinkedIn. Last year, we registered 30 million students and recent graduates on the site – the fastest-growing demographic," Gibney said. "Young people entering the workforce expect companies to have a presence on social media, whether that's in the recruitment process, ways of delivering learning or internal messaging."

The Accenture report said HR should play an essential role in creating effective incentives and organisational structures relating to knowledge sharing.

Gibney says HR should not restrict social media use because it may be perceived as a negative gesture towards employees.

Instead, HR should take the initiative, wresting control of social media from IT and marketing, as it will ultimately start to influence organisations' bottom lines.

Recently, a study by the Chartered Institute of Personnel Development suggested that companies should allow their employees more freedom to use online portals.

It said that organisations tend to restrict the use of social media platforms to prevent sensitive information being compromised and guard against cyber crime.

Many employees, however, believe social media helps them to respond to customer queries and helps to give them a voice, enabling them to contribute to the running of a company. 

Categories
Micro-biology

New protein study could aid cancer drug development

New research into the role played by dysfunction of regulatory proteins that keep an oncogene in check could lead to the developments in drugs used to treat head and neck cancers.

Previous research has revealed activation and signalling of a protein known as Signal Transducer and Activator of Transcription 3 (STAT3) in many cancers. The increased activity of this protein is often associated with poor prognosis. In adult tissues, proteins that promote the growth and development of cancer cells are triggered by STAT3.

The new study, conducted at the University of Pittsburgh School of Medicine, could provide a reason for the hyperactivation of STAT3 and help to develop new drugs.

It was noted that STAT3 did not commonly occur in head and neck cancers so the team looked for mutations in other proteins associated with STAT3.

A phosphate group needs to be added to STAT3 in order to activate it. Cancer drugs tend to work by inhibiting enzymes that encourage this process.

However, the team focussed on the process by which enzymes known as phosphatases deactivate proteins by removing the phosphatases.

It was discovered that head and neck tumours with high levels of STAT3 were linked with mutations in the PTPR group of phosphatases. Computational and lab models were developed to replicate the mutations and it was found that they led to dysfunction of the enzymes.

Jennifer Grandis, distinguished professor of otolaryngology at the Pitt School of Medicine, and director of the head and neck program at the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter, said: "Because the phosphatases don't work properly, phosphate groups don't get removed from STAT3 appropriately, and it stays activated. These mutations essentially get rid of the brakes that might otherwise slow or even stop cancer development."

Tumours could be screened for mutations to the PTPR group and they could be treated with drugs that inhibit STAT3's activity.

The team's findings are published in the early online version of the Proceedings of the National Academy of Sciences.

Categories
Life Sciences

Research reveals effect of vitamin D on child development

A new study has revealed links between vitamin D levels in pregnant mothers and muscle strength in children.

According to research conducted at the Medical Research Council Lifecourse Epidemiology Unit (MRC LEU) at the University of Southampton, children are more likely to have stronger muscles if vitamin D levels in their mothers' bodies are high during pregnancy.

A link has previously been made between low levels of vitamin D and reduced muscle strength in adults but little has been known about the effects of varying levels of the vitamin in pregnant mothers on their children.

Scientists conducting the study measured vitamin D levels in the bodies of 678 mothers in the later stages of pregnancy. Grip strength and muscle mass were measured in the children when they were four years old.

It was found that grip strength is stronger among children of mothers who had higher levels of vitamin D in their bodies. An increase in muscle mass was also discovered, although the link with vitamin D levels was less pronounced in this case.

Low levels of vitamin D are common among British women, who frequently fail to supplement their diet – even though taking additional quantities is recommended.

Lead researcher Dr Nicholas Harvey, senior lecturer at the MRC LEU at the University of Southampton, said the research may have wider implications. He pointed out that a low grip strength among children is often associated with health problems which develop in adults, including diabetes, falls and fractures. 

Greater vitamin D levels in pregnant mothers may therefore help to reduce the likelihood of developing these conditions in later life.

The research formed part of the Southampton Women's Survey, one of the largest of such studies conducted globally.

Cyrus Cooper, professor of rheumatology and director of the MRC LEU at the University of Southampton, said the latest results are part of a wider project to determine the effects of mothers' diet and lifestyle on children's development. "This work should help us to design interventions aimed at optimising body composition in childhood and later adulthood and thus improve the health of future generations," he commented.

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HR Information

New study highlights importance of trust in the workplace

A deficit of trust among workforces could harm the UK's economic recovery, according to a new report.

The study, Are organisations losing the trust of their workers?, highlights the importance of trust in motivating employees. The CIPD report found that employees who do not trust their senior managers are less likely to be productive and engaged.

Only around a third of employees (37 per cent) trust senior management, according to the results of the survey.

The report explores the factors behind weak employee trust, the consequences of a decline in trust and the ways in which it may be restored.

It finds that trust among employees may have been damaged by the recession and its aftermath. Recent improvements in levels of trust may be a consequence of the economic recovery.

Leadership, culture and behaviour are all major factors in establishing and maintaining trust. It is stronger when management is seen to treat people fairly and when leaders act in accordance with corporate values. Trust is reciprocal: when leaders show trust in their employees, employees tend to trust managers.

In low trust environments, employees are less likely to take risks and share knowledge, which can have the effect of stifling innovation. Additionally, if people feel unable to hold the behaviour of leaders to account, it may have a detrimental effect on an organisation's performance and reputation.

The study identifies ways of improving trust when it has been lost or damaged. These include improving communication and giving employees a stronger voice. Systems and behaviour should be seen to reinforce corporate values.

Mark Beatson, chief economist at the CIPD, said: "Trust is an economic issue. If employees do not trust their leaders, this damages business performance. Employees spend more time covering their backs and trying to second guess what management are up to. They are much less likely to be engaged in their work; indeed, they are more likely to be looking for another job and are unlikely to recommend their employer to anyone else."

A short-term improvement in trust levels may be occurring due to economic recovery but this needs to be consolidated using the means identified above.

Categories
Micro-biology

Research identifies way to boost corneal transplant success

New research at the University of Texas South Western Medical Centre has identified a potential method of improving the odds of corneal transplant acceptance.

In a study conducted on mice, researchers found that blocking the action of an immune system molecule called interferon-gamma (IFN-y) led to corneal transplants being accepted 90 per cent of the time when the mice shared the same major histocompatibility complex (MHC) genotype as the donor cornea.

"Our findings indicate that neither MHC matching alone nor administration of anti-IFN-y antibody alone enhances graft survival. However, we found that when MHC matching is combined with anti-IFN-y therapy, long-term corneal transplant survival is almost guaranteed," said Dr Jerry Niederkorn, professor of ophthalmology and microbiology at UT Southwestern and senior author of the study.

Corneal transplants are a common operation. However, the body rejects the transplant in an estimated ten per cent of patients and the odds of a second procedure being successful are poor.

Surprisingly, the study found that IFN-y could act as an immune system suppressor or activator. Whether it does so depends on the context of the histocompatibility antigens perceived by the immune system. 

Earlier studies found that IFN-y caused the immune system to reject transplants and disabling it would improve acceptance rates. But the new research found that the rejection rate was 100 per cent when IFN-y is disabled and there is no MHC matching between the mice and the transplants.

In the latter case, IFN-y was needed to maintain the T-regulatory cells that suppress the body's immune response.

Dr Niederkorn suggested that transplant matching and inactivation of IFN-γ would make most sense for those individuals whose bodies have already rejected a cornea or those believed to be at risk of rejection, rather than all first-time recipients. 

Further study is necessary before a clinical trial can take place. The team are currently attempting to develop an IFN-γ antibody in eye-drop form but they will need to test this in animal models.